Beyond its ramifications for Citigroup as a global financial company, the departure of John Reed also raises some questions about e-Citi, the technology development unit of Citigroup that includes its Internet bank, Citi f/i.

The effort was just the latest on the technology front championed by Mr. Reed, who is often described as a visionary in the area. However, e-Citi's development came at a major cost; analysts estimate it has racked up hundreds of millions of dollars in losses over the last two years.

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