After buying Lehman Brothers Holdings Inc.'s North American operations at the peak of the financial crisis, British bank Barclays PLC is on the prowl for another major acquisition in the U.S., according to people close to the matter.

Barclays is hunting for a retail bank that would give it more deposits and extend the presence of Barclays Capital in the U.S., these people said. In response to potential changes in banking regulation, it has designated an internal team to assess possible targets, they said. It is not in talks with any U.S. company, however, and no deal is imminent, they said.

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